TY - JOUR
T1 - FABP3 protein promotes α-synuclein oligomerization associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity
AU - Shioda, Norifumi
AU - Yabuki, Yasushi
AU - Kobayashi, Yuka
AU - Onozato, Misaki
AU - Owada, Yuji
AU - Fukunaga, Kohji
PY - 2014/7/4
Y1 - 2014/7/4
N2 - Background: αSyn toxicity is triggered by oligomerization of αSyn, and its formation is partly regulated by PUFAs. Results: MPTP-induced neurotoxicity and αSyn oligomerization are attenuated in Fabp3-/- mice. Conclusion: FABP3 is implicated in arachidonic acid-induced αSyn oligomerization and promotes dopaminergic cell death. Significance: FABP3 aggravates MPTP-induced neuronal toxicity and αSyn accumulation.
AB - Background: αSyn toxicity is triggered by oligomerization of αSyn, and its formation is partly regulated by PUFAs. Results: MPTP-induced neurotoxicity and αSyn oligomerization are attenuated in Fabp3-/- mice. Conclusion: FABP3 is implicated in arachidonic acid-induced αSyn oligomerization and promotes dopaminergic cell death. Significance: FABP3 aggravates MPTP-induced neuronal toxicity and αSyn accumulation.
UR - http://www.scopus.com/inward/record.url?scp=84903852279&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903852279&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.527341
DO - 10.1074/jbc.M113.527341
M3 - Article
C2 - 24855640
AN - SCOPUS:84903852279
VL - 289
SP - 18957
EP - 18965
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 27
ER -