FABP3 protein promotes α-synuclein oligomerization associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity

Norifumi Shioda, Yasushi Yabuki, Yuka Kobayashi, Misaki Onozato, Yuji Owada, Kohji Fukunaga

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: αSyn toxicity is triggered by oligomerization of αSyn, and its formation is partly regulated by PUFAs. Results: MPTP-induced neurotoxicity and αSyn oligomerization are attenuated in Fabp3-/- mice. Conclusion: FABP3 is implicated in arachidonic acid-induced αSyn oligomerization and promotes dopaminergic cell death. Significance: FABP3 aggravates MPTP-induced neuronal toxicity and αSyn accumulation.

Original languageEnglish
Pages (from-to)18957-18965
Number of pages9
JournalJournal of Biological Chemistry
Volume289
Issue number27
DOIs
Publication statusPublished - 2014 Jul 4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'FABP3 protein promotes α-synuclein oligomerization associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity'. Together they form a unique fingerprint.

  • Cite this