Extranodal NK/T-cell lymphoma mimicking granulomatous myositis

Norihiko Kawaguchi, Rumiko Izumi, Masahiro Kobayashi, Maki Tateyama, Naoki Suzuki, Fumiyoshi Fujishima, Juichi Fujimori, Masashi Aoki, Ichiro Nakashima

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive non-Hodgkin lymphoma that typically develops in the upper aerodigestive tract. We encountered an ENKTL patient who presented with generalized muscle weakness with eyelid swelling, diplopia, and facial edema. A muscle biopsy revealed lymphocytic infiltration without significant atypia; some lymphocytes formed granuloma-like structures. Although the initial response to steroids was encouraging, an ulcerative eruption appeared in the thigh, and a skin biopsy revealed lymphocytes with atypia. A re-analysis of the muscle biopsy with additional immunohistochemistry revealed neoplastic NK/T lymphocytes in the granulomatous structures. Our case highlights the significance of reevaluating muscle biopsy specimens in cases of atypical myositis.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalInternal Medicine
Issue number2
Publication statusPublished - 2019 Jan 15


  • Extranodal NK/T-cell lymphoma (ENKTL)
  • Eyelid swelling
  • Granulomatous myositis
  • Immunohistochemistry
  • Muscle biopsy

ASJC Scopus subject areas

  • Internal Medicine


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