Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation

Kentaro Ariyoshi, Yota Hiroyama, Naoya Fujiwara, Tomisato Miura, Kosuke Kasai, Akifumi Nakata, Yohei Fujishima, Valerie Swee Ting Goh, Mitsuaki A. Yoshida

Research output: Contribution to journalArticlepeer-review

Abstract

Alopecia is one of the common symptoms after high-dose radiation exposure. In our experiments, neonatal mice that received 7 Gy X-ray exhibited defects in overall hair growth, except for their cheeks. This phenomenon might suggest that some substances were secreted and prevented hair follicle loss in the infant tissues around their cheeks after radiation damage. In this study, we focused on exosome-like vesicles (ELV) secreted from cheek skin tissues and back skin tissues, as control, and examined their radiation protective effects on mouse fibroblast cell lines. We observed that ELV from irradiated cheek skin showed protective effects from radiation. Our results suggest that ELV from radiation-exposed cheek skin tissue is one of the secreted factors that prevent hair follicle loss after high-dose radiation.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalJournal of radiation research
Volume62
Issue number1
DOIs
Publication statusPublished - 2021 Jan 1

Keywords

  • animal model
  • extracellular vesicles
  • radiation protection
  • skin tissue

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Extracellular vesicles released from irradiated neonatal mouse cheek tissue increased cell survival after radiation'. Together they form a unique fingerprint.

Cite this