Extracellular electron transfer across bacterial cell membranes via a cytocompatible redox-active polymer

Koichi Nishio, Ryuhei Nakamura, Xiaojie Lin, Tomohiro Konno, Kazuhiko Ishihara, Shuji Nakanishi, Kazuhito Hashimoto

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A redox-active phospholipid polymer with a phospholipid-mimicking structure (2-methacryloyloxyethyl phosphorylcholine; MPC) was synthesized to construct a biocompatible electron mediator between bacteria and an electrode. In this study, a copolymer of MPC and vinylferrocene [VF; poly(MPC-co-VF)] (PMF) is synthesized. When PMF is added to cultures of the bacterial species Escherichia coli (Gram negative) and Lactobacillus plantarum (Gram positive), which have different cell wall structures, a catalytic current mediated by PMF is observed. In addition, growth curves and live/dead assays indicate that PMF does not decrease metabolic activity or cell viability. These results indicate that PMF mediates extracellular electron transfer across bacterial cell membranes without associated cytotoxicity.

Original languageEnglish
Pages (from-to)2159-2163
Number of pages5
JournalChemPhysChem
Volume14
Issue number10
DOIs
Publication statusPublished - 2013 Jul 22
Externally publishedYes

Keywords

  • cytotoxicity
  • electrochemistry
  • electron transfer
  • microbiology
  • phospholipids

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Physical and Theoretical Chemistry

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