Extended affinity-guided DMAP chemistry with a finely tuned acyl donor for intracellular FKBP12 labeling

Zhining Song, Yousuke Takaoka, Yoshiyuki Kioi, Kazuhiro Komatsu, Tomonori Tamura, Takayuki Miki, Itaru Hamachi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We successfully extended affinity-guided DMAP (AGD) chemistry with a reactivity-tuned acyl donor library that is capable of the selective and efficient labeling of FKBP12 in living cells as well as in test tube. The new AGD chemistry provides great promise for the establishment of selective intracellular protein functionalization or imaging methods.

Original languageEnglish
Pages (from-to)333-335
Number of pages3
JournalChemistry Letters
Volume44
Issue number3
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Chemistry(all)

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