Expression profiling with progression of dystrophic change in dysferlin-deficient mice (SJL)

Naoki Suzuki, Masashi Aoki, Yuji Hinuma, Toshiaki Takahashi, Yoshiaki Onodera, Aya Ishigaki, Masaaki Kato, Hitoshi Warita, Maki Tateyama, Yasuto Itoyama

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The SJL mouse is a model for human dysferlinopathy (limb-girdle muscular dystrophy type 2B and Miyoshi myopathy). We used cDNA microarrays to compare the expression profiles of 10,012 genes in control and SJL quadriceps femoris muscles in order to find genes involved in the degeneration and regeneration process and in dysferlin's functional network. Many genes involved in the process of muscle regeneration are observed to be up-regulated in SJL mice, including cardiac ankyrin repeated protein (CARP), Neuraminidase 2, interleukin-6, insulin-like growth factor-2 and osteopontin. We found the upregulation of S100 calcium binding proteins, neural precursor cell expressed, developmentally down-regulated gene 4-like (NEDD4L) with C2 domain, and intracellular protein traffic associated proteins (Rab6 and Rab2). These proteins have the potential to interact with dysferlin. We must reveal some other molecules which may work with dysferlin in order to clarify the pathological network of dysferlinopathy. This process may lead to future improvements in the therapy for human dysferlinopathy.

Original languageEnglish
Pages (from-to)47-60
Number of pages14
JournalNeuroscience Research
Volume52
Issue number1
DOIs
Publication statusPublished - 2005 May

Keywords

  • C2 domain
  • Dysferlin
  • Microarray
  • Miyoshi myopathy
  • Muscular dystrophy
  • SJL mouse

ASJC Scopus subject areas

  • Neuroscience(all)

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