Expression of vasohibin-2 in pancreatic ductal adenocarcinoma promotes tumor progression and is associated with a poor clinical outcome

Jung Chul Kim, Kyung Tae Kim, Jong Tae Park, Hyun Jong Kim, Yasufumi Sato, Hyung Seok Kim

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

This study aimed to assess the expression of vasohibin-2 (VASH2) in pancreatic ductal adenocarcinoma (PDAC) as a marker of tumor aggressiveness and its impact on tumor angiogenesis, proliferation, and clinical outcome. We examined the expression of the VASH2 gene in human pancreatic cell lines PANC-1 and MiaPaCa-2 by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunocytochemistry. Fifty samples from patients with PDAC were immunostained with VASH2, CD34, and Ki-67 antibodies. Further, the immunoreactivity of VASH2 correlated with the pathological features, including microvessel density (MVD), tumor cell proliferation (Ki-67 labeling index), and survival. Forty-seven of the 50 samples from PDAC patients showed immunoreactivity for VASH2 along the tumor cell cytoplasm. Among the VASH2-positive samples, 22 were categorized as high VASH2 expression group, and this group had statistical significance with pN stage (p = 0.006), UICC stage (p = 0.033), tumor proliferation (p < 0.001), and MVD (p = 0.017). Moreover, patients with high VASH2 expression showed worse prognosis compared to those showing low VASH2 expression (overall logrank p = 0.003). Thus, our results suggested that overexpression of VASH2 accelerated the pace of tumor development toward a more serious malignant phenotype and was associated with a poor clinical outcome. VASH2 may be an important novel target for the management of PDAC after surgery.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalHepato-Gastroenterology
Volume62
Issue number138
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • Pancreatic ductal adenocarcinoma
  • Prognosis
  • Tumor angiogenesis
  • Vasohibin-2

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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