Expression of variant ribosomal RNA genes in mouse oocytes and preimplantation embryos

Motomasa Ihara, Hung Tseng, Richard M. Schultz

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Ribosomal DNA (rDNA) is not composed of multiple copies of identical transcription units, as commonly believed, but rather of at least seven rDNA variant subtypes that are expressed in somatic cells. This finding raises the possibility that ribosome function may be modulated as proposed by the ribosome filter hypothesis. We report here that mouse oocytes and preimplantation embryos express all the rDNA variants except variant V and that there is no marked developmental change in the qualitative pattern of variant expression. The maternal and embryonic ribosome pools are therefore quite similar, minimizing the likelihood that developmental changes in composition of the ribosome population are critical for preimplantation development.

Original languageEnglish
Pages (from-to)944-946
Number of pages3
JournalBiology of Reproduction
Volume84
Issue number5
DOIs
Publication statusPublished - 2011 May

Keywords

  • Early development
  • Embryo
  • Gametogenesis
  • Oocyte development
  • rDNA

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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