Expression of tumor necrosis factor-α in muscles of polymyositis

M. Tateyama, I. Nagano, M. Yoshioka, K. Chida, S. Nakamura, Y. Itoyama

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

We immunohistochemically examined biopsied muscles from nine untreated patients with polymyositis (PM) and five patients with other neuromuscular diseases (ONMD), using monoclonal antibodies to tumor necrosis factor-α (TNF-α) and lymphoid surface markers. In muscles of three patients with PM, we observed many TNF-α positive macrophages and lymphocytes in endomysium and around vessels in the muscles. By contrast, there were few, weakly TNF-α stained cells in muscles of three patients with ONMD. The ratio of TNF-α-positive cells to the muscle fibers and the ratio of TNF-α-positive cells to the mononuclear cells were significantly higher in PM compared with ONMD. In addition, we obsered atrophic muscle fibers more frequently in TNF-α-positive muscles than TNF-α-negative ones. We conclude that, at least, in a part of PM patients, TNF-α produced locally may contribute to the pathogenesis of PM.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of the neurological sciences
Volume146
Issue number1
DOIs
Publication statusPublished - 1997 Feb 27
Externally publishedYes

Keywords

  • immunohistochemistry
  • lymphocyte subsets
  • polymyositis
  • tumor necrosis factor-α

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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