Expression of tumor necrosis factor-α in muscles of polymyositis

M. Tateyama, I. Nagano, M. Yoshioka, K. Chida, S. Nakamura, Y. Itoyama

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    35 Citations (Scopus)

    Abstract

    We immunohistochemically examined biopsied muscles from nine untreated patients with polymyositis (PM) and five patients with other neuromuscular diseases (ONMD), using monoclonal antibodies to tumor necrosis factor-α (TNF-α) and lymphoid surface markers. In muscles of three patients with PM, we observed many TNF-α positive macrophages and lymphocytes in endomysium and around vessels in the muscles. By contrast, there were few, weakly TNF-α stained cells in muscles of three patients with ONMD. The ratio of TNF-α-positive cells to the muscle fibers and the ratio of TNF-α-positive cells to the mononuclear cells were significantly higher in PM compared with ONMD. In addition, we obsered atrophic muscle fibers more frequently in TNF-α-positive muscles than TNF-α-negative ones. We conclude that, at least, in a part of PM patients, TNF-α produced locally may contribute to the pathogenesis of PM.

    Original languageEnglish
    Pages (from-to)45-51
    Number of pages7
    JournalJournal of the neurological sciences
    Volume146
    Issue number1
    DOIs
    Publication statusPublished - 1997 Feb 27

    Keywords

    • immunohistochemistry
    • lymphocyte subsets
    • polymyositis
    • tumor necrosis factor-α

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

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  • Cite this

    Tateyama, M., Nagano, I., Yoshioka, M., Chida, K., Nakamura, S., & Itoyama, Y. (1997). Expression of tumor necrosis factor-α in muscles of polymyositis. Journal of the neurological sciences, 146(1), 45-51. https://doi.org/10.1016/S0022-510X(96)00280-8