Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue

Takeshi Oshima, Katsuhisa Ikeda, Masayuki Furukawa, Hideaki Suzuki, Tomonori Takasaka

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

In the present study, ClC-3, one of the voltage-dependent chloride channels, was identified in human nasal tissue. In situ hybridization and immunohistochemical investigations demonstrated the localization of ClC-3 in the serous acini and ductal portions of submucosal nasal glands, which are the primary source of nasal secretion. Our data suggest that this channel contributes to nasal secretion via chloride transport. Its dysfunction might lead to abnormal nasal secretion in such pathological states as sinusitis.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalORL
Volume63
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • Chloride channel
  • ClC-3
  • Submucosal nasal gland

ASJC Scopus subject areas

  • Otorhinolaryngology

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