Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue

Takeshi Oshima; Katsuhisa Ikeda; Masayuki Furukawa; Hideaki Suzuki; Tomonori Takasaka

doi:10.1159/000055715

Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue

Takeshi Oshima, Katsuhisa Ikeda, Masayuki Furukawa, Hideaki Suzuki, Tomonori Takasaka

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

In the present study, ClC-3, one of the voltage-dependent chloride channels, was identified in human nasal tissue. In situ hybridization and immunohistochemical investigations demonstrated the localization of ClC-3 in the serous acini and ductal portions of submucosal nasal glands, which are the primary source of nasal secretion. Our data suggest that this channel contributes to nasal secretion via chloride transport. Its dysfunction might lead to abnormal nasal secretion in such pathological states as sinusitis.

Original language	English
Pages (from-to)	82-86
Number of pages	5
Journal	ORL
Volume	63
Issue number	2
DOIs	https://doi.org/10.1159/000055715
Publication status	Published - 2001

Keywords

Chloride channel
ClC-3
Submucosal nasal gland

ASJC Scopus subject areas

Otorhinolaryngology

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10.1159/000055715

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abstract = "In the present study, ClC-3, one of the voltage-dependent chloride channels, was identified in human nasal tissue. In situ hybridization and immunohistochemical investigations demonstrated the localization of ClC-3 in the serous acini and ductal portions of submucosal nasal glands, which are the primary source of nasal secretion. Our data suggest that this channel contributes to nasal secretion via chloride transport. Its dysfunction might lead to abnormal nasal secretion in such pathological states as sinusitis.",

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author = "Takeshi Oshima and Katsuhisa Ikeda and Masayuki Furukawa and Hideaki Suzuki and Tomonori Takasaka",

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T1 - Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue

AU - Oshima, Takeshi

AU - Ikeda, Katsuhisa

AU - Furukawa, Masayuki

AU - Suzuki, Hideaki

AU - Takasaka, Tomonori

PY - 2001

Y1 - 2001

N2 - In the present study, ClC-3, one of the voltage-dependent chloride channels, was identified in human nasal tissue. In situ hybridization and immunohistochemical investigations demonstrated the localization of ClC-3 in the serous acini and ductal portions of submucosal nasal glands, which are the primary source of nasal secretion. Our data suggest that this channel contributes to nasal secretion via chloride transport. Its dysfunction might lead to abnormal nasal secretion in such pathological states as sinusitis.

AB - In the present study, ClC-3, one of the voltage-dependent chloride channels, was identified in human nasal tissue. In situ hybridization and immunohistochemical investigations demonstrated the localization of ClC-3 in the serous acini and ductal portions of submucosal nasal glands, which are the primary source of nasal secretion. Our data suggest that this channel contributes to nasal secretion via chloride transport. Its dysfunction might lead to abnormal nasal secretion in such pathological states as sinusitis.

KW - Chloride channel

KW - ClC-3

KW - Submucosal nasal gland

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ER -

Expression of the voltage-dependent chloride channel CIC-3 in human nasal tissue

Abstract

Keywords

ASJC Scopus subject areas

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