Expression of the Sox10 gene during mouse inner ear development

Ken ichi Watanabe; Kazuhisa Takeda; Yukio Katori; Katsuhisa Ikeda; Takeshi Oshima; Ken ichi Yasumoto; Hideo Saito; Tomonori Takasaka; Shigeki Shibahara

doi:10.1016/S0169-328X(00)00236-9

Expression of the Sox10 gene during mouse inner ear development

Ken ichi Watanabe, Kazuhisa Takeda, Yukio Katori, Katsuhisa Ikeda, Takeshi Oshima, Ken ichi Yasumoto, Hideo Saito, Tomonori Takasaka, Shigeki Shibahara

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	141-145
Number of pages	5
Journal	Molecular Brain Research
Volume	84
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(00)00236-9
Publication status	Published - 2000 Dec 8

Keywords

Cochlea
Inner ear
Organ of Corti
Otic vesicle
Sox10
Supporting cell

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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title = "Expression of the Sox10 gene during mouse inner ear development",

abstract = "Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V.",

keywords = "Cochlea, Inner ear, Organ of Corti, Otic vesicle, Sox10, Supporting cell",

author = "Watanabe, {Ken ichi} and Kazuhisa Takeda and Yukio Katori and Katsuhisa Ikeda and Takeshi Oshima and Yasumoto, {Ken ichi} and Hideo Saito and Tomonori Takasaka and Shigeki Shibahara",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (B), for Scientific Research on Priority Areas, and for Encouragement of Young Scientist (to K. Y.) from the Ministry of Education, Science, Sports and Culture of Japan. This work was also supported in part by the Nakatomi Foundation and the Kao Foundation for Arts and Sciences.",

year = "2000",

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doi = "10.1016/S0169-328X(00)00236-9",

language = "English",

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T1 - Expression of the Sox10 gene during mouse inner ear development

AU - Watanabe, Ken ichi

AU - Takeda, Kazuhisa

AU - Katori, Yukio

AU - Ikeda, Katsuhisa

AU - Oshima, Takeshi

AU - Yasumoto, Ken ichi

AU - Saito, Hideo

AU - Takasaka, Tomonori

AU - Shibahara, Shigeki

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (B), for Scientific Research on Priority Areas, and for Encouragement of Young Scientist (to K. Y.) from the Ministry of Education, Science, Sports and Culture of Japan. This work was also supported in part by the Nakatomi Foundation and the Kao Foundation for Arts and Sciences.

PY - 2000/12/8

Y1 - 2000/12/8

N2 - Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V.

AB - Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V.

KW - Cochlea

KW - Inner ear

KW - Organ of Corti

KW - Otic vesicle

KW - Sox10

KW - Supporting cell

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Expression of the Sox10 gene during mouse inner ear development

Abstract

Keywords

ASJC Scopus subject areas

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