Expression of the Sox10 gene during mouse inner ear development

Ken ichi Watanabe, Kazuhisa Takeda, Yukio Katori, Katsuhisa Ikeda, Takeshi Oshima, Ken ichi Yasumoto, Hideo Saito, Tomonori Takasaka, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalMolecular Brain Research
Volume84
Issue number1-2
DOIs
Publication statusPublished - 2000 Dec 8

Keywords

  • Cochlea
  • Inner ear
  • Organ of Corti
  • Otic vesicle
  • Sox10
  • Supporting cell

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Expression of the Sox10 gene during mouse inner ear development'. Together they form a unique fingerprint.

Cite this