Expression of the labial group Hox gene HrHox-1 and its alteration induced by retinoic acid in development of the ascidian Halocynthia roretzi

Y. Katsuyama, S. Wada, S. Yasugi, H. Saiga

    Research output: Contribution to journalArticle

    107 Citations (Scopus)

    Abstract

    Ascidian embryogenesis shares several developmental features with vertebrates. Thus, it is presumed that some molecular mechanisms that are critical for vertebrate development may also act in the early development of ascidians. Here, we investigated expression of the ascidian labial group Hox gene HrHox-1 in the development of Halocynthia roretzi. HrHox-1 showed a spatially restricted expression pattern along the anterior-posterior axis, which is remarkably similar to that of the vertebrate gene, Hoxb-1. The expression of HrHox-1, however, was exclusively in tissues of ectoderm origin unlike its vertebrate counterpart. Exposure of the embryos to 10-6 M all-trans retinoic acid induced a larval phenotype with elimination of the anteriormost structures, the papillae. In this phenotype, the level of HrHox-1 expression was enhanced and ectopic expression was observed at the anterior terminal epidermis where the papillae are otherwise formed. These observations suggest that there are some conserved mechanisms in the spatial regulation of expression of labial group genes in embryogenesis of ascidians and vertebrates.

    Original languageEnglish
    Pages (from-to)3197-3205
    Number of pages9
    JournalDevelopment
    Volume121
    Issue number10
    Publication statusPublished - 1995 Jan 1

    Keywords

    • Ascidian
    • Gene expression
    • Hox gene
    • Labial group gene
    • Moonfaced phenotype
    • Retinoic acid

    ASJC Scopus subject areas

    • Cell Biology
    • Anatomy

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