TY - JOUR
T1 - Expression of the interleukin-2 receptor γ chain on cord blood mononuclear cells
AU - Saito, Shigeru
AU - Morii, Takeshi
AU - Umekage, Hideshi
AU - Makita, Kaori
AU - Nishikawa, Kiyoshi
AU - Narita, Nobuhiro
AU - Ichijo, Motohiko
AU - Morikawa, Hajime
AU - Ishii, Naoto
AU - Nakamura, Masataka
AU - Sugamura, Kazuo
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1996/4/15
Y1 - 1996/4/15
N2 - Lymphocytes in umbilical cord blood and neonatal peripheral blood have been shown to have less ability in an immune reaction. In our present experimental approach to address this issue, we made use of the cord blood of full-term birth infants to investigate the expression of the interleukin-2 receptor γ (IL-2Rγ) chain that is shared with receptors for IL-4, IL-7, IL- 9, and IL-15 as well as IL-2. The γ chain expression in cord blood lymphocytes was about one-third that in the lymphocytes of adults, whereas no significant difference between cord blood and adult monocytes was observed. A reduced expression of the γ chain was observed in all of the CD4+ T cells, CD8+ T cells, γδ T cells, B cells, CD16+ natural killer (NK) cells, and CD56(bright) NK cells of the cord blood lymphocytes. The reduced γ chain expression reached two-thirds of that in adults after 3 days of culture in vitro and in infants 3 days after birth, thus implying that the increase in the γ chain may significantly contribute to the prevention of neonatal infection.
AB - Lymphocytes in umbilical cord blood and neonatal peripheral blood have been shown to have less ability in an immune reaction. In our present experimental approach to address this issue, we made use of the cord blood of full-term birth infants to investigate the expression of the interleukin-2 receptor γ (IL-2Rγ) chain that is shared with receptors for IL-4, IL-7, IL- 9, and IL-15 as well as IL-2. The γ chain expression in cord blood lymphocytes was about one-third that in the lymphocytes of adults, whereas no significant difference between cord blood and adult monocytes was observed. A reduced expression of the γ chain was observed in all of the CD4+ T cells, CD8+ T cells, γδ T cells, B cells, CD16+ natural killer (NK) cells, and CD56(bright) NK cells of the cord blood lymphocytes. The reduced γ chain expression reached two-thirds of that in adults after 3 days of culture in vitro and in infants 3 days after birth, thus implying that the increase in the γ chain may significantly contribute to the prevention of neonatal infection.
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U2 - 10.1182/blood.v87.8.3344.bloodjournal8783344
DO - 10.1182/blood.v87.8.3344.bloodjournal8783344
M3 - Article
C2 - 8605351
AN - SCOPUS:15844421032
VL - 87
SP - 3344
EP - 3350
JO - Blood
JF - Blood
SN - 0006-4971
IS - 8
ER -