Expression of the insulinoma gene rig during liver regeneration and in primary cultured hepatocytes

Chiyoko Inoue, Kazuhiko Igarashi, Motoo Kitagawa, Kimio Terazono, Shin Takasawa, Ken ichi Obata, Kazushi Iwata, Hiroshi Yamamoto, Hiroshi Okamoto

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We have isolated a novel gene, rig (rat insulinoma gene) from rat insulinomas. In the present study, rig was found to be expressed in rat regenerating liver and in primary cultured rat hepatocytes. The level of rig mRNA was increased at the proliferative phase of liver regeneration. In synchronously cultured hepatocytes, the rig mRNA level was elevated at the G1 phase of the cell cycle and the rig-protein was accumulated in the nuclei during the S phase. These results indicated that rig could be involved in a more general way in growth or cell replication.

Original languageEnglish
Pages (from-to)1302-1308
Number of pages7
JournalBiochemical and biophysical research communications
Volume150
Issue number3
DOIs
Publication statusPublished - 1988 Feb 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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