Expression of strawberry notch family genes during zebrafish embryogenesis

Ai Takano, Riyo Zochi, Masahiko Hibi, Toshio Terashima, Yu Katsuyama

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Our previous study suggested a possible role for Sbno1, a mouse homologue of strawberry notch gene during brain development. In this report, we cloned the zebrafish homologues of sbno, and examined their expression pattern during embryogenesis by whole-mount in situ hybridization. Zebrafish have three sbno genes: one Sbno1 homologue and two Sbno2 homologues, sbno2a and sbno2b. We observed that the expression of sbno1 and sbno2a was initially ubiquitous and gradually became predominant in the central nervous system as development progressed. The expression of sbno2b was observed in non-neural tissues in contrast to the other two genes. sbno1 and sbno2a exhibited higher expression in distinct regions within the nervous system of pharyngula-stage embryos, suggesting possible differing roles for sbno1 and sbno2a during later stages of embryogenesis. Together, the observed gene expression patterns suggest an important role of sbno-family genes during development of the vertebrate central nervous system.

    Original languageEnglish
    Pages (from-to)1789-1796
    Number of pages8
    JournalDevelopmental Dynamics
    Volume239
    Issue number6
    DOIs
    Publication statusPublished - 2010 Jan 1

    Keywords

    • Brain development
    • Gene expression
    • Strawberry notch
    • Zebrafish

    ASJC Scopus subject areas

    • Developmental Biology

    Fingerprint Dive into the research topics of 'Expression of strawberry notch family genes during zebrafish embryogenesis'. Together they form a unique fingerprint.

  • Cite this

    Takano, A., Zochi, R., Hibi, M., Terashima, T., & Katsuyama, Y. (2010). Expression of strawberry notch family genes during zebrafish embryogenesis. Developmental Dynamics, 239(6), 1789-1796. https://doi.org/10.1002/dvdy.22287