Expression of somatostatin type 2A receptor correlates with estrogen receptor in human breast carcinoma

Monika Pilichowska, Noriko Kimura, Marcus Schindler, Akihiko Suzuki, Ryuichi Yoshida, Hiroshi Nagura

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Somatostatin type 2A receptor (sstr2A) has been shown to be directly involved in the transduction of antiproliferative effects and also to be the most predominant sstr subtype in human normal breast epithelium, as well as in human breast carcinoma. We investigated the immunoreactivity of sstr2A in 34 cases of human breast carcinoma and correlated these findings with the immunoreactivity of the estrogen receptor (ER), epidermal growth factor receptor (EGFR), transforming growth factor α (TGFα) and insulin like growth factor I (IGF-I). We detected sstr2A immunoreactivity in normal mammary tissue, and in 27 of 34 (79%) breast carcinomas. The sstr2A immunoreactivity was localized on the cellular membrane, however, weak cytoplasmic immunoreactivity was also observed. Sstr2A immunoreactivity was heterogeneously distributed in the whole tumor section. There was a statistically significant correlation between sstr2A and ER immunoreactivity in the same tumor. No statistically significant correlation was found between sstr2A immunoreactivity and immunoreactivity for EGFR, TGFα and IGF-I or the patients' age.

Original languageEnglish
Pages (from-to)57-67
Number of pages11
JournalEndocrine Pathology
Volume11
Issue number1
Publication statusPublished - 2000 Jan 1

Keywords

  • Breast carcinoma
  • Immunohistochemistry
  • Somatostatin receptor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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