Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development

Noriko Osumi-Yamashita, Sumihare Noji, Tsutomu Nohno, Eiki Koyama, Hirofumi Doi, Kazuhiro Eto, Shigehiko Taniguchi

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalFEBS Letters
Volume264
Issue number1
DOIs
Publication statusPublished - 1990 May 7
Externally publishedYes

Keywords

  • Embryo
  • Expression pattern
  • Facial development
  • In situ hybridization
  • Neural crest cell
  • Retinoic acid receptor gene

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development'. Together they form a unique fingerprint.

Cite this