Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development

Noriko Osumi-Yamashita; Sumihare Noji; Tsutomu Nohno; Eiki Koyama; Hirofumi Doi; Kazuhiro Eto; Shigehiko Taniguchi

doi:10.1016/0014-5793(90)80767-D

Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development

Noriko Osumi-Yamashita, Sumihare Noji, Tsutomu Nohno, Eiki Koyama, Hirofumi Doi, Kazuhiro Eto, Shigehiko Taniguchi

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	FEBS Letters
Volume	264
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(90)80767-D
Publication status	Published - 1990 May 7
Externally published	Yes

Keywords

Embryo
Expression pattern
Facial development
In situ hybridization
Neural crest cell
Retinoic acid receptor gene

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Access to Document

10.1016/0014-5793(90)80767-D

Cite this

@article{c8da73caf07e47ef896d06d8edd2257d,

title = "Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development",

abstract = "Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.",

keywords = "Embryo, Expression pattern, Facial development, In situ hybridization, Neural crest cell, Retinoic acid receptor gene",

author = "Noriko Osumi-Yamashita and Sumihare Noji and Tsutomu Nohno and Eiki Koyama and Hirofumi Doi and Kazuhiro Eto and Shigehiko Taniguchi",

note = "Funding Information: ~ckn~wle~ge~ent~: We thank Drs Pierre Chambon, Martin Petkovich, and Arthur Zeientf or donationo f the mouseR ARo, p and y cDNAs. This work was supportedi n part by a Grant (no. 63570870f)r om the JapaneseM inistry of Education, Sciencea nd Culture.",

year = "1990",

month = may,

day = "7",

doi = "10.1016/0014-5793(90)80767-D",

language = "English",

volume = "264",

pages = "71--74",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development

AU - Osumi-Yamashita, Noriko

AU - Noji, Sumihare

AU - Nohno, Tsutomu

AU - Koyama, Eiki

AU - Doi, Hirofumi

AU - Eto, Kazuhiro

AU - Taniguchi, Shigehiko

N1 - Funding Information: ~ckn~wle~ge~ent~: We thank Drs Pierre Chambon, Martin Petkovich, and Arthur Zeientf or donationo f the mouseR ARo, p and y cDNAs. This work was supportedi n part by a Grant (no. 63570870f)r om the JapaneseM inistry of Education, Sciencea nd Culture.

PY - 1990/5/7

Y1 - 1990/5/7

N2 - Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.

AB - Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.

KW - Embryo

KW - Expression pattern

KW - Facial development

KW - In situ hybridization

KW - Neural crest cell

KW - Retinoic acid receptor gene

UR - http://www.scopus.com/inward/record.url?scp=0025317322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025317322&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(90)80767-D

DO - 10.1016/0014-5793(90)80767-D

M3 - Article

C2 - 2159896

AN - SCOPUS:0025317322

VL - 264

SP - 71

EP - 74

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 1

ER -

Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this