TY - JOUR
T1 - Expression of retinoic acid receptor genes in neural crest-derived cells during mouse facial development
AU - Osumi-Yamashita, Noriko
AU - Noji, Sumihare
AU - Nohno, Tsutomu
AU - Koyama, Eiki
AU - Doi, Hirofumi
AU - Eto, Kazuhiro
AU - Taniguchi, Shigehiko
N1 - Funding Information:
~ckn~wle~ge~ent~: We thank Drs Pierre Chambon, Martin Petkovich, and Arthur Zeientf or donationo f the mouseR ARo, p and y cDNAs. This work was supportedi n part by a Grant (no. 63570870f)r om the JapaneseM inistry of Education, Sciencea nd Culture.
PY - 1990/5/7
Y1 - 1990/5/7
N2 - Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.
AB - Retinoic acid (RA) is known as a teratogen that induces abnormalities in facial structures which are made up mainly of neural crest-derived mesenchyme. We investigated expression patterns of RA receptor (RAR) genes (subtypes α, β, γ) during mouse facial development. The expression of the rarβ gene is specific for the mesenchyme around developing eyes and nose, whereas the RARγ gene is expressed in the mesenchyme differentiating to facial cartilages and bones. In contrast, the RARα gene is expressed weakly and uniformly over the facial region. These results suggest that crucial roles of endogenous RA in facial development depend on differential functions of the RAR subtypes.
KW - Embryo
KW - Expression pattern
KW - Facial development
KW - In situ hybridization
KW - Neural crest cell
KW - Retinoic acid receptor gene
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U2 - 10.1016/0014-5793(90)80767-D
DO - 10.1016/0014-5793(90)80767-D
M3 - Article
C2 - 2159896
AN - SCOPUS:0025317322
VL - 264
SP - 71
EP - 74
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -