Expression of pancreatic secretory trypsin inhibitor gene in human colorectal tumor

Naohiro Tomita, Sadayuki Doi, Masahiko Higashiyama, Hideki Morimoto, Masahiro Murotani, Yasuhito Kawasaki, Takushi Monden, Takashi Shimano, Akira Horii, Hideoki Yokouchi, Michio Ogawa, Takesada Mori, Kenichi Matsubara

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22 Citations (Scopus)

Abstract

Expression of pancreatic secretory trypsin inhibitor (PSTI) gene was examined by Northern blotting analyses in 31 human colorectal tumors that included two benign adenomas and 26 adenocarcinomas. Among the total of 28 cases which proved to be adequate for mRNA analyses, all but one showed the expression of PSTI at various levels. in contrast, PSTI expression was not detected in two malignant lymphomas of the rectum. the level of PSTI expression was not correlated with the patient's age, sex, tumor location or size, stage of differentiation, lymph node metastasis, or progression stage. Some colorectal adenocarcinomas were also shown to express genes that can hybridize with human trypsinogen cDNA probe. It looks as though in these tumors, a protease(s) and its inhibitor are produced simultaneously as part of a cellular self‐defense mechanism.

Original languageEnglish
Pages (from-to)2144-2149
Number of pages6
JournalCancer
Volume66
Issue number10
DOIs
Publication statusPublished - 1990 Jan 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Tomita, N., Doi, S., Higashiyama, M., Morimoto, H., Murotani, M., Kawasaki, Y., Monden, T., Shimano, T., Horii, A., Yokouchi, H., Ogawa, M., Mori, T., & Matsubara, K. (1990). Expression of pancreatic secretory trypsin inhibitor gene in human colorectal tumor. Cancer, 66(10), 2144-2149. https://doi.org/10.1002/1097-0142(19901115)66:10<2144::AID-CNCR2820661017>3.0.CO;2-#