Expression of OX40 in muscles of polymyositis and granulomatous myopathy

Maki Tateyama, Kazuo Fujihara, Naoto Ishii, Kazuo Sugamura, Yoshiaki Onodera, Yasuto Itoyama

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


OX40 is selectively expressed on activated autoreactive memory T cells and these OX40+ lymphocytes may play a crucial role in autoimmune diseases. To determine whether OX40+ lymphocytes are involved in the pathomechanism of human inflammatory muscle diseases, we immunohistochemically examined the distribution of OX40+ cells in muscles from patients with polymyositis and granulomatous myopathy, and compared with that of cells bearing other activation markers, such as IL-2 receptor (IL-2R) and HLA-DR. In polymyositis, OX40+ mononuclear cells were found predominantly in the perivascular sites and to a lesser degree in the endomysium. Scanty IL-2R+ mononuclear cells were located only in the endomysium and HLA-DR was expressed on half of the mononuclear cells distributed diffusely in the perivascular sites and in the endomysium. Mononuclear cell infiltration in the perivascular sites was greater in the muscles in which OX40+ cells were present in the perivascular sites than in those without OX40+ cells in the perivascular sites (p<0.05). In granulomatous myopathy, OX40+ cells were detected in the centers of the granulomas. In contrast, IL-2R+ cells were present at the periphery of the granulomas and HLA-DR was detected on mononuclear cells throughout the granulomas. OX40+ mononuclear cells with specific distributions in muscles may be involved in the pathomechanism of polymyositis and granulomatous myopathy, and can be a candidate molecule of selective immunotherapy in these diseases.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of the neurological sciences
Issue number1
Publication statusPublished - 2002 Feb 15


  • Granulomatous myopathy
  • HLA-DR
  • IL-2R
  • Immunohistochemistry
  • OX40
  • Polymyositis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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