Expression of NUDEL in manchette and its implication in spermatogenesis

Noritaka Yamaguchi, Yasukazu Takanezawa, Hiroyuki Koizumi, Makiko Umezu-Goto, Junken Aoki, Hiroyuki Arai

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Nuclear distribution gene E-like product (NUDEL) is a mammal homologue of fungal NUDE and is involved in neuronal migration during brain development. High levels of NUDEL were expressed in murine testis as well as brain. During spermatogenesis, NUDEL was not detected until postnatal day 12 (P12), rising to significant levels at P27. NUDEL was localized predominantly along microtubules of the manchette in elongated spermatids. In maturing spermatids, NUDEL was observed only in the centrosomes, while mature testicular spermatozoa did not show any NUDEL expression. These results suggest that NUDEL plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalFEBS Letters
Issue number1-3
Publication statusPublished - 2004 May 21


  • Cdk5, Cyclin-dependent kinase 5
  • LIS1
  • Manchette
  • Microtubule
  • NUDE, Nuclear distribution gene E product
  • NUDEL, NUDE-like
  • PAF-AH, Platelet-activating factor acetylhydrolase
  • Spermatogenesis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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