Expression of myostatin in neural cells of the olfactory system

Shunsuke Iwasaki, Masato Miyake, Hitoshi Watanabe, Eri Kitagawa, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Hisashi Aso

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)


    Recent studies show that myostatin mRNA expression is found in some regions of the brain. However, the functional significance of this is currently unknown. We therefore investigated myostatin expression and function in the brain. In this study, we used immunohistochemistry, in situ hybridization, and RT-PCR analysis to reveal that myostatin is expressed in the mitral cells in the olfactory bulb (OB) and in neurons in the olfactory cortex (OC). Using 3D reconstruction, mitral cells positive for myostatin were positioned in the lateral and ventral regions of the OB. In contrast, myostatin-positive mitral cells were detected in mice at 2 weeks of age, but not on days 0 and 7 after birth. Activin receptor IIB, a myostatin receptor, was expressed in the OB, OC, hippocampus, and paraventricular thalamic nucleus. Moreover, c-Fos immunostaining in granule cells in the OB was augmented after intracerebroventricular injection of myostatin. These findings suggest that myostatin is localized in specific cells associated with the olfactory system of the brain and may act as a key inhibitor in cell and/or signal development of the olfactory system.

    Original languageEnglish
    Pages (from-to)1-8
    Number of pages8
    JournalMolecular Neurobiology
    Issue number1
    Publication statusPublished - 2013 Feb


    • Brain
    • Intracerebroventricular injection
    • Myostatin
    • Neurogenesis
    • Olfactory system

    ASJC Scopus subject areas

    • Neurology
    • Cellular and Molecular Neuroscience


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