Expression of microglial response factor-1 in microglia and macrophages following cerebral ischemia in the rat

Hiroyuki Kato, Shuuitsu Tanaka, Takanori Oikawa, Tatsuro Koike, Akira Takahashi, Yasuto Itoyama

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Microglial response factor-1 is a newly isolated microglial gene, which encodes a Ca2+ binding protein MRF-1 expressed in microglia and macrophages. We induced 1 h of focal cerebral ischemia or 10 min of global cerebral ischemia in the rat, and investigated the expression of MRF-1 immunoreactivity following ischemia. MRF-1 was present in resting microglia and was upregulated in response to microglial activation. MRF-1 was localized to all the cells of the mononuclear phagocyte system (microglia, monocytes, and perivascular cells) that appeared in the ischemic brain. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalBrain research
Volume882
Issue number1-2
DOIs
Publication statusPublished - 2000 Nov 3

Keywords

  • Cerebral ischemia
  • Macrophage
  • Microglia
  • Microglial response factor-1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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