TY - JOUR
T1 - Expression of microglial response factor-1 in microglia and macrophages following cerebral ischemia in the rat
AU - Kato, Hiroyuki
AU - Tanaka, Shuuitsu
AU - Oikawa, Takanori
AU - Koike, Tatsuro
AU - Takahashi, Akira
AU - Itoyama, Yasuto
N1 - Funding Information:
This study was supported in part by the Grant-in-Aid for Scientific Research (No. 11670606) from the Ministry of Education, Science, and Culture of Japan.
PY - 2000/11/3
Y1 - 2000/11/3
N2 - Microglial response factor-1 is a newly isolated microglial gene, which encodes a Ca2+ binding protein MRF-1 expressed in microglia and macrophages. We induced 1 h of focal cerebral ischemia or 10 min of global cerebral ischemia in the rat, and investigated the expression of MRF-1 immunoreactivity following ischemia. MRF-1 was present in resting microglia and was upregulated in response to microglial activation. MRF-1 was localized to all the cells of the mononuclear phagocyte system (microglia, monocytes, and perivascular cells) that appeared in the ischemic brain. (C) 2000 Elsevier Science B.V.
AB - Microglial response factor-1 is a newly isolated microglial gene, which encodes a Ca2+ binding protein MRF-1 expressed in microglia and macrophages. We induced 1 h of focal cerebral ischemia or 10 min of global cerebral ischemia in the rat, and investigated the expression of MRF-1 immunoreactivity following ischemia. MRF-1 was present in resting microglia and was upregulated in response to microglial activation. MRF-1 was localized to all the cells of the mononuclear phagocyte system (microglia, monocytes, and perivascular cells) that appeared in the ischemic brain. (C) 2000 Elsevier Science B.V.
KW - Cerebral ischemia
KW - Macrophage
KW - Microglia
KW - Microglial response factor-1
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U2 - 10.1016/S0006-8993(00)02811-0
DO - 10.1016/S0006-8993(00)02811-0
M3 - Article
C2 - 11056201
AN - SCOPUS:0034602244
VL - 882
SP - 206
EP - 211
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1-2
ER -