Expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) in cerebral cavernous malformations: Immunohistochemical analysis of MMP-2, -9 and TIMP-2

M. Fujimura, M. Watanabe, H. Shimizu, T. Tominaga

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Object. Hemorrhage from cerebral vascular malformations such as cerebral cavernous malformation (CCM) can result in significant mortality and morbidity, but its underlying mechanism is undetermined. Excessive degradation of the vascular matrix by matrix metalloproteinases (MMPs), proteolytic enzymes that degrade all the components of extracellular matrix, can lead to instability of the vascular structure and can thereby cause bleeding. Thus we examined the expression of MMPs and tissue inhibitors of metalloproteinase (TIMP) in CCM. Patients and methods. We performed immunohistochemistry for MMP-2, -9, and TIMP-2 using Paraffin-embedded sections of the surgical specimens obtained from seven patients with CCM. All patients had a history of hemorrhage from CCM. Findings. In all patients (7/7, 100%), MMP-2 and -9 were strongly expressed in endothelial cells of CCMs. Endothelial expression of TIMP-2 was also evident in all seven patients. In contrast, MMP-2, -9 and TIMP-2 were not identified in adjacent normal brain tissue. Conclusion. We found that CCM showed the increased endothelial expression of MMP-2, -9, and TIMP-2. Endothelial expression of MMPs and/or TIMP may affect the vascular matrix stability, and thus can contribute to hemorrhage from CCM.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalActa neurochirurgica
Volume149
Issue number2
DOIs
Publication statusPublished - 2007 Feb

Keywords

  • Cerebral cavernous malformation (CCM)
  • Hemorrhage
  • Immunohistochemistry
  • Matrix metalloproteinases

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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