Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells

Yasuka L. Yamaguchi, Satomi S. Tanaka, Miyuki Kasa, Kunio Yasuda, Patrick P.L. Tam, Yasuhisa Matsui

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The low density lipoprotein receptor-related protein 4 gene (Lrp4) was identified by subtractive screening of cDNAs of the migratory primordial germ cells (PGCs) of E8.5-9.5 embryo and E3.5 blastocysts. Lrp4 is expressed in PGCs in the hindgut and the dorsal mesentery of E9.5 embryos, and in germ cells in the genital ridges of male and female E10.5-13.5 embryos. Lrp4 is also expressed in spermatogonia of the neonatal and adult testes and in the immature oocytes and follicular cells of the adult ovary. The absence of Lrp4 expression in the blastocyst, embryonic stem cells and embryonic germ cells suggests the Lrp4 is a molecular marker that distinguishes the germ cells from embryo-derived pluripotent stem cells.

Original languageEnglish
Pages (from-to)607-612
Number of pages6
JournalGene Expression Patterns
Volume6
Issue number6
DOIs
Publication statusPublished - 2006 Aug

Keywords

  • Germ cells
  • Low density lipoprotein receptor-related protein 4
  • Lrp4
  • Mouse
  • PGCs

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology

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