Expression of insulin-like growth factor 1 receptor in primary breast cancer: Immunohistochemical analysis

Chikako Shimizu, Tadashi Hasegawa, Yoichi Tani, Fumiaki Takahashi, Masahiro Takeuchi, Toru Watanabe, Masashi Ando, Noriyuki Katsumata, Yasuhiro Fujiwara

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

Insulin-like growth factor-1 receptor (IGF-1R) has been implicated in regulation in tumor growth. The results of previous studies performed by radioimmunoassay are conflicting, and the prognostic significance of IGF-1R expression in primary breast cancer is still controversial. IGF-1R expression was evaluated in formalin-fixed, paraffin-embedded tissue of 210 primary breast cancer patients by using anti-IGF-1R antibody. The clinicopathologic variables and 5-year disease-free survival were studied, and their correlations between IGF-1R expressions were investigated. IGF-1R overexpression was observed in 43.8% of tumors. IGF-1R overexpression had no correlation with prognosis or with other clinicopathologic parameters, such as age, tumor size, nodal status, histologic grade, hormone receptor status, and human epidermal growth factor 2 status. Though its prognostic value in breast cancer is limited, immunohistochemical evaluation of IGF-1R by using this monoclonal antibody may be useful in translational research using archived material.

Original languageEnglish
Pages (from-to)1537-1542
Number of pages6
JournalHuman Pathology
Volume35
Issue number12
DOIs
Publication statusPublished - 2004 Dec 1
Externally publishedYes

Keywords

  • ER
  • HER2
  • IGF-1R
  • IGF-binding proteins
  • IGFBPs
  • Insulin-like growth factor 1 receptor
  • PR
  • estrogen receptor
  • immunohistochemistry
  • insulin-like growth factor-1 receptor
  • primary breast cancer
  • progesterone receptor
  • prognostic marker

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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