Expression of hypothalamic corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency: A report of an autopsied case

T. Mori, Yoshio Murakami, M. Nishiki, K. Koshimura, H. Sasano, Y. Kato

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A 77-yr-old man died of metastising adenocarcinoma of the lung. He had been treated with hydrocortisone for isolated ACTH deficiency for 9 yr. At autopsy, the pituitary and the adrenal glands were atrophic. Lymphocyte infiltration was not observed in the pituitary, the adrenal and the thyroid glands. Immunohistochemistry revealed selective loss of ACTH-like immunoreactivity in the pituitary gland whereas CRH-immunoreactive cells were found in the paraventricular nucleus of the hypothalamus. This is the first report demonstrating immunohistochemical examinations of the pituitary and the hypothalamus in isolated ACTH deficiency.

Original languageEnglish
Pages (from-to)556-559
Number of pages4
JournalJournal of Endocrinological Investigation
Volume26
Issue number6
DOIs
Publication statusPublished - 2003 Jun
Externally publishedYes

Keywords

  • Corticotropin-releasing hormone
  • Immunohistochemistry
  • Isolated ACTH deficiency

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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