Expression of heme oxygenase gene in rat and human liver

Nader G. Abraham, Jane H.C. Lin, Steve M. Mitrione, Michal L. Schwartzman, Richard D. Levere, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Developmental changes of microsomal heme oxygenase were studied. In human fetal liver, the enzyme activity was 8 times higher than that detected in the adult liver. On the other hand, adult livers contained 4 times more cytochrome P450 than fetal livers. Elevated heme oxygenase activity in fetal liver was not due to modulators present in the microsomes. Similar to human, rat fetal liver also contained high enzyme activity which appeared to be regulated at the transcriptional level. Hybridization analysis of rat liver RNAs with cDNA for rat heme oxygenase revealed that the level of mRNA for the enzyme was 3-fold higher in the fetus than in the adult. The low cytochrome P450 content may be due in part to the high heme oxygenase activity in fetal livers.

Original languageEnglish
Pages (from-to)717-722
Number of pages6
JournalBiochemical and biophysical research communications
Volume150
Issue number2
DOIs
Publication statusPublished - 1988 Jan 29

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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