Expression of gp34 (OX40 ligand) and OX40 on human T cell clones

Naruhiko Takasawa, Naoto Ishii, Norikazu Higashimura, Kazuko Murata, Yuetsu Tanaka, Masataka Nakamura, Takeshi Sasaki, Kazuo Sugamura

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalJapanese Journal of Cancer Research
Volume92
Issue number4
DOIs
Publication statusPublished - 2001

Keywords

  • Gp34
  • OX40
  • OX40ligand (OX40L)
  • T cell clones

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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