Expression of gp34 (OX40 ligand) and OX40 on human T cell clones

Naruhiko Takasawa; Naoto Ishii; Norikazu Higashimura; Kazuko Murata; Yuetsu Tanaka; Masataka Nakamura; Takeshi Sasaki; Kazuo Sugamura

doi:10.1111/j.1349-7006.2001.tb01105.x

Expression of gp34 (OX40 ligand) and OX40 on human T cell clones

Naruhiko Takasawa, Naoto Ishii, Norikazu Higashimura, Kazuko Murata, Yuetsu Tanaka, Masataka Nakamura, Takeshi Sasaki, Kazuo Sugamura

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.

Original language	English
Pages (from-to)	377-382
Number of pages	6
Journal	Japanese Journal of Cancer Research
Volume	92
Issue number	4
DOIs	https://doi.org/10.1111/j.1349-7006.2001.tb01105.x
Publication status	Published - 2001

Keywords

Gp34
OX40
OX40ligand (OX40L)
T cell clones

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Expression of gp34 (OX40 ligand) and OX40 on human T cell clones",

abstract = "gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.",

keywords = "Gp34, OX40, OX40ligand (OX40L), T cell clones",

author = "Naruhiko Takasawa and Naoto Ishii and Norikazu Higashimura and Kazuko Murata and Yuetsu Tanaka and Masataka Nakamura and Takeshi Sasaki and Kazuo Sugamura",

year = "2001",

doi = "10.1111/j.1349-7006.2001.tb01105.x",

language = "English",

volume = "92",

pages = "377--382",

journal = "Cancer Science",

issn = "1347-9032",

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T1 - Expression of gp34 (OX40 ligand) and OX40 on human T cell clones

AU - Takasawa, Naruhiko

AU - Ishii, Naoto

AU - Higashimura, Norikazu

AU - Murata, Kazuko

AU - Tanaka, Yuetsu

AU - Nakamura, Masataka

AU - Sasaki, Takeshi

AU - Sugamura, Kazuo

PY - 2001

Y1 - 2001

N2 - gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.

AB - gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.

KW - Gp34

KW - OX40

KW - OX40ligand (OX40L)

KW - T cell clones

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DO - 10.1111/j.1349-7006.2001.tb01105.x

M3 - Article

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AN - SCOPUS:0035025030

VL - 92

SP - 377

EP - 382

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

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