TY - JOUR
T1 - Expression of gp34 (OX40 ligand) and OX40 on human T cell clones
AU - Takasawa, Naruhiko
AU - Ishii, Naoto
AU - Higashimura, Norikazu
AU - Murata, Kazuko
AU - Tanaka, Yuetsu
AU - Nakamura, Masataka
AU - Sasaki, Takeshi
AU - Sugamura, Kazuo
PY - 2001
Y1 - 2001
N2 - gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.
AB - gp34, Which we previously cloned, is a ligand of OX40 (CD134), a costimulatory molecule involved in T cell activation. To elucidate the role of human OX40/OX40L interaction, we examined the expression of gp34 (OX40L) and OX40 in normal human hematopoietic cells by using flow cytometry. OX40 expression is observed on activated T cells, while OX40L is expressed in antigen-presenting cells. However, cytotoxic T lymphocyte (CTL) clones specific for Epstein-Barr virus (EBV)-transformed autologous lymphoblastic cell lines (LCLs) induced both OX40 and OX40L expression after antigen or T cell receptor (TCR) stimulation. This study suggests a possible function of OX40L/OX40, through T cell-T cell interaction, in the reactivation of memory T cells in an autocrine manner, with implications for the pathogenesis of viral infections and neoplasms.
KW - Gp34
KW - OX40
KW - OX40ligand (OX40L)
KW - T cell clones
UR - http://www.scopus.com/inward/record.url?scp=0035025030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035025030&partnerID=8YFLogxK
U2 - 10.1111/j.1349-7006.2001.tb01105.x
DO - 10.1111/j.1349-7006.2001.tb01105.x
M3 - Article
C2 - 11346458
AN - SCOPUS:0035025030
VL - 92
SP - 377
EP - 382
JO - Cancer Science
JF - Cancer Science
SN - 1347-9032
IS - 4
ER -