Expression of glutathione S‐transferase‐π messenger rna in human esophageal cancers

Chikashi Ishioka, Ryunosuke Kanamaru, Hiroyuki Shibata, Yukari Konishi, Akira Ishikawa, Akira Wakui, Toshiaki Sato, Tetsuro Nishihira

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The expression of human glutathione S‐transferase‐π (GST‐π) in resected primary esophageal tumors and in matching normal esophageal mucosa from 25 patients undergoing radical surgery was measured by RNA blot hybridization. The RNA transcript levels of GST‐π in the tumor tissues were higher than those in normal tissues in 20 of 25 cases (80%). The mean GST‐π mRNA value in the tumor tissues (n = 25) was significantly (P < 0.01) elevated as compared with that in background mucosa (n = 29), and in ten of 25 tumors (40%) the level of GST‐π mRNA exceeded the mean normal tissue value by two standard deviations (normal mean value + 2 × SD). The results obtained from the current experiment thus suggests that GST‐π might be a useful marker for human esophageal cancer. No correlation between GST‐π mRNA level and clinical stage or histologic characteristics was apparent.

Original languageEnglish
Pages (from-to)2560-2564
Number of pages5
JournalCancer
Volume67
Issue number10
DOIs
Publication statusPublished - 1991 May 15

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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