Expression of glucose transporter isof orms with aging

Yoshitomo Oka, Tomoichiro Asano, Jiann Liang Lin, Katsunori Tsukuda, Hideki Katagiri, Hisamitsu Ishihara, Kouichi Inukai, Yoshio Yazaki

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

To elucidate the cellular mechanisms for impairment of glucose metabolism associated with aging, the facilitative glucose transporter protein and mRNA were studied in various tissues of young (7-week-old) and aged (20-month-old) rats. GLUT4 glucose transporter protein, a major glucose transporter iso-form in the insulin-responsive tissues, was selectively decreased in the epididymal fat tissues of the aged rats compared with the young rats. This decrease is likely to be due to a decrease in protein synthesis rather than in protein stability. since GLUT4 mRNA per unit cellular total RNA was also decreased. GLUT4 mRNA in the skeletal muscle was rather increased in spite of the decreased level of GLUT4 protein in the aged rats, suggesting that the translational efficiency and/or stability of GLUT4 protein is decreased in the skeletal muscle of the aged rats compared with the young rats. In contrast to these alterations in GLUT4 expression, no apparent decrease in the GLUT1 protein amount was observed in the fat tissues, skeletal muscle and brain of the aged rats compared with the young rats. Thus, the tissue and isoform-specific alterations in glucose transporter expression are associated with aging and may contribute to impairment of glucose metabolism observed with aging.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalGerontology
Volume38
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Keywords

  • Glucose transporter
  • Glucose transporter mRNA

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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