Expression of erythropoietin and erythropoietin receptor in peritoneal endometriasis

Sachiko Matsuzaki, Michel Canis, Rei Yokomizo, Nobuo Yaegashi, Maurice A. Bruhat, Kunihiro Okamura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were significantly higher than those with stages II, III and IV of the disease. Therefore, we hypothesized that Epo may play a role in the pathogenesis of endometriosis, particularly during the early stages of the disease. Method: We investigated the localization of Epo and the Epo receptor (Epo-R) in peritoneal endometriosis and eutopic endometrium, using immunohistochemistry. Results: We detected Epo and Epo-R localized within glandular epithelial cells in both peritoneal endometriosis and eutopic endometrium. There was no significant difference in Epo expression between red and black peritoneal lesions, whereas Epo-R expression was significantly lower in black peritoneal lesions when compared to red lesions. Epo and Epo-R expression levels within red peritoneal lesions were comparable to those of eutopic endometrium from patients with endometriosis. Conclusion: The present findings suggest that Epo may play a role in the pathophysiology of endometriosis.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalHuman Reproduction
Issue number1
Publication statusPublished - 2003 Jan 1


  • Black endometriotic lesions
  • Erythropoietin
  • Erythropoietin-receptor
  • Red endometriotic lesions

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


Dive into the research topics of 'Expression of erythropoietin and erythropoietin receptor in peritoneal endometriasis'. Together they form a unique fingerprint.

Cite this