Expression of epidermal growth factor-related proteins and epidermal growth factor receptor in common epithelial ovarian tumors

Hitoshi Niikura, Hironobu Sasano, Shinji Sato, Akira Yajima

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70 Citations (Scopus)


The biologic significance of epidermal growth factor (EGF)-related proteins and EGF receptor (EGFR) in the development and progression of human ovarian carcinoma was studied in 17 ovarian cystadenomas, 6 mucinous tumors of loW malignant potential (LMP) and 25 invasive adenocarcinomas by immunohistochemistry. Results were correlated with clinicopathologic features. We also examined immunoreactivity in five serous adenocarcinomas both before and after cisplatin chemotherapy. Amphiregulin (AR) expression was observed only in mutinous tumors (4 of 8 cystadenomas, 2 of 6 tumors of LMP, and 6 of 10 cystadenocarcinomas), but was not detected in the serous tumors or clear cell adenocarcinomas. EGF, cripto, and EGFR expression was significantly higher in mucinous cystadenocarcinomas than in mucinous cystadenomas or mucinous tumors of LMP. Three of five specimens obtained at a second operation after chemotherapy had more intense or diffuse immunostaining for transforming growth factor α (TGF-α) than the initial specimens did. Coexpression of more than two of the EGF-related proteins or EGFR significantly correlated with increased surgical stage in serous and clear cell carcinoma. AR expression seems to correlate with mutinous differentiation rather than with advanced stages of ovarian tumors. Our results indicate that expression of some EGF-related proteins is greater in certain subtypes of ovarian carcinomas than in their benign counterparts and that coexpression of these proteins is associated with advanced stage in serous and clear cell carcinoma. Increased TGF-α expression may also be related to ovarian tumor resistance to cisplatin chemotherapy.

Original languageEnglish
Pages (from-to)60-68
Number of pages9
JournalInternational Journal of Gynecological Pathology
Issue number1
Publication statusPublished - 1997 Jan


  • Carcinoma
  • EGF family
  • EGFR
  • Immunohistochemistry Ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology


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