Expression of cytochrome P‐450lpr Is developmentally regulated and limited to house fly

Geoffrey D. Wheelock, Yasuhiko Konno, Jeffrey G. Scott

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16 Citations (Scopus)


Expression of house fly cytochrome P‐450lpr was examined using immunoblotting in male and female adult LPR house flies, mixed sex adult house flies at 12 different ages, larvae, and pupae. P‐450lpr was expressed in both male and female adult house flies. P‐450lpr was clearly present in all adult stages examined, was barely detectable in pupae, and could not be detected in larvae. Thus, cytochrome P‐450lpr is developmentally regulated and present in both sexes of house fly. Expression of cytochrome P‐450, immunologically homologous to house fly cytochrome P‐450lpr was examined in other species using immunoblot analysis. Eleven animal species were tested in the orders Diptera, Hymenoptera, Lepidoptera, Orthoptera, Acari, and Rodentia, using microsomes in some species from both induced and noninduced animals or insecticide‐resistant and susceptible strains. P‐450lpr appears to be restricted to house flies, as none of these species contained cytochrome P‐450 that reacted with antiserum to cytochrome P‐450lpr.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalJournal of Biochemical Toxicology
Issue number4
Publication statusPublished - 1991 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology


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