Expression of connexin 31 in the developing mouse cochlea

An Ping Xia, Katsuhisa Ikeda, Yukio Katori, Takeshi Oshima, Toshihiko Kikuchi, Tomonori Takasaka

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Connexin 31 (Cx31) mutations cause an autosomal dominant form of high-frequency hearing loss. The immunohistochemical localization of Cx31 in mouse cochlea was studied at different ages between 0 and 60 days after birth (DAB). Cx31-like immunoreactivity was detected in fibrocytes of spiral ligament and spiral limbus at 12 DAB, gradually enhanced with the increase of age and reached the adult pattern on 60 DAB. Immunoreactivity decreased gradually from the basal to apical turn in all developmental stages. The mRNA of Cx31 was also identified by RT-PCR. The distribution of Cx31 and connexin 26 were obviously different in the developing mouse cochlea. The expression and distribution of Cx31 in the development may explain the progressive hearing loss in human Cx31 mutations. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)2449-2453
Number of pages5
JournalNeuroReport
Volume11
Issue number11
DOIs
Publication statusPublished - 2000 Aug 3

Keywords

  • Connexin 31
  • Development
  • Fibrocyte
  • Gap junction
  • Hearing impairment
  • RT-PCR
  • Spiral ligament

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Xia, A. P., Ikeda, K., Katori, Y., Oshima, T., Kikuchi, T., & Takasaka, T. (2000). Expression of connexin 31 in the developing mouse cochlea. NeuroReport, 11(11), 2449-2453. https://doi.org/10.1097/00001756-200008030-00022