Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas

Kennichi Satoh, Tooru Shimosegawa, Masaru Koizumi, Takayoshi Toyota

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The expression of alternatively spliced CD44 isoforms, especially so-called variant exons v5 and v6, has been shown to correlate with the progression of a number of human cancers examined the expression of standard CD44 and CD44 variants with exons v5 and v6 in 28 cases of human pancreatic tumors (16 cases of invasive duct cell adenocarcinoma and 12 cases of intraductal neoplasms) by immunohistochemistry using exon specific monoclonal antibodies. The expression of standard CD44 was frequently observed in both invasive duct cell carcinomas and intraductal neoplasms. The expression of CD44 variants (v5 and v6) was also seen in almost all cell duct carcinomas. In contrast, intraductal neoplasms infrequently expressed CD44-v5 and v6, particularly v6 exon. Expression of CD44-v5 and v6 was a common characteristic of invasive cancer, while it was not so prominent in intraductal neoplasm. These finding may be related to the invasiveness of duct cell carcinoma and/or the benign biological behavior of intraductal neoplasm of the pancreas.

Original languageEnglish
Pages (from-to)215-219
Number of pages5
JournalAnticancer research
Volume17
Issue number1 A
Publication statusPublished - 1997 Mar 25

Keywords

  • CD44
  • Cancer
  • Human
  • Intraductal neoplasm
  • Pancreas

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Satoh, K., Shimosegawa, T., Koizumi, M., & Toyota, T. (1997). Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas. Anticancer research, 17(1 A), 215-219.