TY - JOUR
T1 - Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry
AU - Sato, Shinji
AU - Jiko, Kumiko
AU - Ito, Kiyoshi
AU - Ozawa, Nobuyoshi
AU - Yajima, Akira
AU - Miyazaki, Shukichi
AU - Sasano, Hironobu
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.
AB - We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.
KW - c-myc mRNA and protein
KW - endometrial carcinoma
KW - immunohistochemistry
KW - in situ hybridization
UR - http://www.scopus.com/inward/record.url?scp=0027639314&partnerID=8YFLogxK
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U2 - 10.1620/tjem.170.229
DO - 10.1620/tjem.170.229
M3 - Article
C2 - 8122249
AN - SCOPUS:0027639314
VL - 170
SP - 229
EP - 234
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 4
ER -