Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry

Shinji Sato; Kumiko Jiko; Kiyoshi Ito; Nobuyoshi Ozawa; Akira Yajima; Shukichi Miyazaki; Hironobu Sasano

doi:10.1620/tjem.170.229

Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry

Shinji Sato, Kumiko Jiko, Kiyoshi Ito, Nobuyoshi Ozawa, Akira Yajima, Shukichi Miyazaki, Hironobu Sasano

Research output: Contribution to journal › Article › peer-review

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Abstract

We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	Tohoku Journal of Experimental Medicine
Volume	170
Issue number	4
DOIs	https://doi.org/10.1620/tjem.170.229
Publication status	Published - 1993

Keywords

c-myc mRNA and protein
endometrial carcinoma
immunohistochemistry
in situ hybridization

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1620/tjem.170.229

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Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry. / Sato, Shinji; Jiko, Kumiko; Ito, Kiyoshi; Ozawa, Nobuyoshi; Yajima, Akira; Miyazaki, Shukichi; Sasano, Hironobu.

In: Tohoku Journal of Experimental Medicine, Vol. 170, No. 4, 1993, p. 229-234.

Research output: Contribution to journal › Article › peer-review

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AU - Ozawa, Nobuyoshi

AU - Yajima, Akira

AU - Miyazaki, Shukichi

AU - Sasano, Hironobu

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Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry

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Keywords

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