Expression of c-myc mRNA and Protein in Human Endometrial Carcinoma; Simultaneous Study of In Situ Hybridization and Immunohistochemistry

Shinji Sato, Kumiko Jiko, Kiyoshi Ito, Nobuyoshi Ozawa, Akira Yajima, Shukichi Miyazaki, Hironobu Sasano

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1 Citation (Scopus)

Abstract

We examined the c-myc gene at both mRNA and protein levels in tumors of 10 endometrial carcinomas by simultaneous in situ hybridization and immunohistochemistry. Expression of c-myc mRNA was observed in all cases by in situ hybridization. Immunohistochemically, c-myc protein expression was also observed in all cases and immunoreactivity was recognized as nuclear staining. The site of c-myc protein expression was mostly consistent with that of c-myc mRNA expression. While there has been no clear correlation between the expression of c-myc mRNA and/or protein and prognostic parameters so far, this approach will contribute to an understanding of oncogene expression and its biological significance in human gynecological malignancies.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalTohoku Journal of Experimental Medicine
Volume170
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • c-myc mRNA and protein
  • endometrial carcinoma
  • immunohistochemistry
  • in situ hybridization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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