Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer

Yan Chen, Masami Sato, Shigefumi Fujimura, Chiaki Endo, Akira Sakurada, Hirokazu Aikawa, Hiroto Takahashi, Tatsuo Tanita, Takashi Kondo, Yasuki Saito, Motoyasu Sagawa

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Background: Apoptosis is regulated by many genes, including bcl-2, p53, and bcl-2 family genes. The expression of Bcl-2, p53, and Bax in very early lung cancers or precancer lesions is not been fully understood. Materials and Methods: The expression of these proteins was examined immunohistochemically in 11 normal bronchial epithelia, 23 dysplasias, and 40 roentgenographically occult squamous cell lung cancers (ROCs). Results: The expression of the Bcl-2 and p53 protein increased along with the advance of the morphological atypia in bronchial epithelial cells, whereas no difference in the Bax expression. The patients with Bcl-2 positive ROCs had a better prognosis than those with Bcl-2 negative ROCs. Conclusions: Bcl-2 and p53 proteins play important roles in early steps of carcinogenesis in squamous cell lung cancer of central type. The Bcl-2 protein could be prognostic marker in ROCs.

Original languageEnglish
Pages (from-to)1351-1355
Number of pages5
JournalAnticancer research
Issue number2 B
Publication statusPublished - 1999


  • Bax
  • Bcl-2
  • Early lung cancer
  • Precancer lesion
  • p53

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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