TY - JOUR
T1 - Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13
AU - Kunii, R.
AU - Nemoto, E.
AU - Kanaya, S.
AU - Tsubahara, T.
AU - Shimauchi, Hidetoshi
PY - 2005/9/1
Y1 - 2005/9/1
N2 - CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.
AB - CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.
KW - CD13
KW - Gingival fibroblast
KW - Human
KW - IL-13
KW - IL-4
UR - http://www.scopus.com/inward/record.url?scp=33646448300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646448300&partnerID=8YFLogxK
U2 - 10.1016/j.ics.2005.07.031
DO - 10.1016/j.ics.2005.07.031
M3 - Review article
AN - SCOPUS:33646448300
VL - 1284
SP - 219
EP - 220
JO - International Congress Series
JF - International Congress Series
SN - 0531-5131
ER -