Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

R. Kunii, E. Nemoto, S. Kanaya, T. Tsubahara, Hidetoshi Shimauchi

Research output: Contribution to journalReview articlepeer-review

Abstract

CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

Original languageEnglish
Pages (from-to)219-220
Number of pages2
JournalInternational Congress Series
Volume1284
DOIs
Publication statusPublished - 2005 Sep 1

Keywords

  • CD13
  • Gingival fibroblast
  • Human
  • IL-13
  • IL-4

ASJC Scopus subject areas

  • Medicine(all)

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