Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

R. Kunii; E. Nemoto; S. Kanaya; T. Tsubahara; Hidetoshi Shimauchi

doi:10.1016/j.ics.2005.07.031

Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

R. Kunii, E. Nemoto, S. Kanaya, T. Tsubahara, Hidetoshi Shimauchi

Research output: Contribution to journal › Review article › peer-review

Abstract

CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

Original language	English
Pages (from-to)	219-220
Number of pages	2
Journal	International Congress Series
Volume	1284
DOIs	https://doi.org/10.1016/j.ics.2005.07.031
Publication status	Published - 2005 Sep 1

Keywords

CD13
Gingival fibroblast
Human
IL-13
IL-4

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.ics.2005.07.031

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title = "Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13",

abstract = "CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.",

keywords = "CD13, Gingival fibroblast, Human, IL-13, IL-4",

author = "R. Kunii and E. Nemoto and S. Kanaya and T. Tsubahara and Hidetoshi Shimauchi",

year = "2005",

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journal = "International Congress Series",

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TY - JOUR

T1 - Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

AU - Kunii, R.

AU - Nemoto, E.

AU - Kanaya, S.

AU - Tsubahara, T.

AU - Shimauchi, Hidetoshi

PY - 2005/9/1

Y1 - 2005/9/1

N2 - CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

AB - CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

KW - CD13

KW - Gingival fibroblast

KW - Human

KW - IL-13

KW - IL-4

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