Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

R. Kunii; E. Nemoto; S. Kanaya; T. Tsubahara; Hidetoshi Shimauchi

doi:10.1016/j.ics.2005.07.031

Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

R. Kunii, E. Nemoto, S. Kanaya, T. Tsubahara, Hidetoshi Shimauchi

Research output: Contribution to journal › Review article › peer-review

Abstract

CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

Original language	English
Pages (from-to)	219-220
Number of pages	2
Journal	International Congress Series
Volume	1284
DOIs	https://doi.org/10.1016/j.ics.2005.07.031
Publication status	Published - 2005 Sep 1

Keywords

CD13
Gingival fibroblast
Human
IL-13
IL-4

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ics.2005.07.031

Cite this

@article{c1aff6afef7b461ebe7c25322660bfeb,

title = "Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13",

abstract = "CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.",

keywords = "CD13, Gingival fibroblast, Human, IL-13, IL-4",

author = "R. Kunii and E. Nemoto and S. Kanaya and T. Tsubahara and Hidetoshi Shimauchi",

year = "2005",

month = sep,

day = "1",

doi = "10.1016/j.ics.2005.07.031",

language = "English",

volume = "1284",

pages = "219--220",

journal = "International Congress Series",

issn = "0531-5131",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

AU - Kunii, R.

AU - Nemoto, E.

AU - Kanaya, S.

AU - Tsubahara, T.

AU - Shimauchi, Hidetoshi

PY - 2005/9/1

Y1 - 2005/9/1

N2 - CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

AB - CD13/aminopeptidase N (APN) is a multifunctional ectoenzyme that is involved in anti-inflammatory reactions, control of immune reactions and differentiation of many cellular systems. In this study, we first demonstrated that CD13/APN was expressed on human gingival fibroblast (hGF). T helper (Th) 2 cell type cytokines such as IL-4 and IL-13, but not IL-2 or IL-15, preferentially increased the expression of CD13/APN, resulting in the inhibition of FMLP-mediated neutrophil activation through the degradation by CD13/APN on HGF. Our data suggested that CD13/APN expressed by hGF could contribute to the anti-inflammatory response in periodontal tissue, and may be involved in disease processes mediated by Th2 cells.

KW - CD13

KW - Gingival fibroblast

KW - Human

KW - IL-13

KW - IL-4

UR - http://www.scopus.com/inward/record.url?scp=33646448300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646448300&partnerID=8YFLogxK

U2 - 10.1016/j.ics.2005.07.031

DO - 10.1016/j.ics.2005.07.031

M3 - Review article

AN - SCOPUS:33646448300

VL - 1284

SP - 219

EP - 220

JO - International Congress Series

JF - International Congress Series

SN - 0531-5131

ER -

Expression of aminopeptidase N/CD13 on human gingival fibroblasts and upregulation upon stimulation with IL-4 and IL-13

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this