Expression of adhesion molecules in cultured human nasal mucosal microvascular endothelial cells activated by interleukin-1β or tumor necrosis factor-α: Effects of dexamethasone

Yuji Yamamoto, Katsuhisa Ikeda, Masako Watanabe, Akira Shimomura, Hideaki Suzuki, Takeshi Oshima, Yoko Imamura, Kazuo Ohuchi, Tomonori Takasaka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine-regulated expression of intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1), and the effect of dexamethasone on these expressions in cultured human nasal microvascular endothelial cells (HNMEC). ICAM-1 was enhanced, and E-selectin and VCAM-1 were induced in a dose-dependent fashion following stimulation with IL-1β or TNF-α. HNMEC differed from human umbilical vein endothelila cells in that (1) maximal upregulation of ICAM-1 expression induced by IL-1β or TNF-α required more time (2) TNF-α was more potent than IL-1β in VCAM-1 expression, and (3) dexamethasone inhibited the upregulation of E-selectin expression alone. These findings contribute to a better understanding of the characteristic features of leukocyte infiltration into inflamed tissue and the effect of glucocorticoid in nonallergic chronic sinusitis.

Original languageEnglish
Pages (from-to)68-77
Number of pages10
JournalInternational archives of allergy and immunology
Volume117
Issue number1
DOIs
Publication statusPublished - 1998 Sep

Keywords

  • Adhesion molecule
  • Cytokine
  • Mucosa, nasal
  • Sinusitis chronic

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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