Expression of a novel member of the ATP1G1/PLM/MAT8 family, phospholemman-like protein (PLP) gene, in the developmental process of mouse cerebellum

Sakae Saito, Ryo Matoba, Kikuya Kato, Kenichi Matsubara

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We have identified a new member of the ATP1G1/PLM/MAT8 family, named phospholemman-like protein (PLP), from a mouse cerebellum cDNA library. The family consists of small transmembrane proteins that modulate the activities of some ion channels. The deduced amino acid sequence of PLP consists of 93 residues that contain the ATP1G1/PLM/MAT8 motif and a single transmembrane domain, and is most similar to the sequence of mouse phospholemman. In situ hybridization analysis showed that the PLP gene is highly expressed in cerebellar granule cells. PLP expression is elevated in the postnatal developing cerebellum. Thus, it may be implicated in the proliferation, differentiation, and axon elongation of granule cells as they mature and migrate to the internal granule layer.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalGene
Volume279
Issue number2
DOIs
Publication statusPublished - 2001 Nov 28
Externally publishedYes

Keywords

  • Adapter-tagged competitive polymerase chain reaction
  • Development
  • Granule cell

ASJC Scopus subject areas

  • Genetics

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