Expression and localization of the Na-K-2Cl cotransporter in the rat cochlea

Satoru Goto, Takeshi Oshima, Katsuhisa Ikeda, Narihisa Ueda, Tomonori Takasaka

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

We identified the localization of the basolateral bumetanide-sensitive Na-K-2Cl cotransporter (BSC2) in the cochlea using an in situ hybridization method. In the rat cochlea, the BSC2 mRNA was mainly expressed in the strial marginal cells. Although the fibrocytes localized at the spiral prominence showed a weak expression of BSC2 mRNA, no expression was observed in the organ of Corti or spiral ganglion cells. The present findings are well consistent with a proposed cell model of ion transport in the marginal cell.

Original languageEnglish
Pages (from-to)324-326
Number of pages3
JournalBrain research
Volume765
Issue number2
DOIs
Publication statusPublished - 1997 Aug 15

Keywords

  • Bumetanide- sensitive Na-K-2Cl cotransporter
  • Fibrocyte
  • Marginal cell
  • Spiral ligament
  • Stria vascularis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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