Expression and cisplatin sensitivity of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinoma cell lines

Kentaro Nakayama, Kohji Miyazaki, Atsuko Kanzaki, Manabu Fukumoto, Yuji Takebayashi

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

One of the most important clinical problems in the treatment of human solid carcinoma is the intrinsic/acquired resistance. Cisplatin is a platinum compound that is one of the most effective agents in clinic. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin resistance by the experiment of transfection of full cDNA of ATP7B into KB3-1 lacking ATP7B. We examined the relationship between mRNA expression level of ATP7B and sensitivity to cisplatin in nine human ovarian carcinoma cell lines to extend these findings. mRNA expression level of ATP7B was significantly correlated with cisplatin-sensitivity in nine cell lines, raising the possibility that ATP7B could be a chemoresistance marker in some types of human solid carcinoma.

Original languageEnglish
Pages (from-to)1285-1287
Number of pages3
JournalOncology reports
Volume8
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • ATP7B
  • Cisplatin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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