Exploration of the characteristics of chronotypes in upper gastrointestinal tract diseases: a multicenter study in Japan

Shu Kiyotoki, Jun Nishikawa, Naoyoshi Nagata, Ryota Niikura, Hisashi Doyama, Atsushi Imagawa, Kenkei Hasatani, Waku Hatta, Tetsuya Sumiyoshi, Hiroko Nebiki, Yasuaki Nagami, Tsutomu Nishida, Naomi Kakushima, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Shiko Kuribayashi, Toshiaki Narasaka, Takuto Hikichi, Tomoyuki YadaYorinari Ochiai, Hiroto Furuhashi, Toshiyuki Yoshio, Hideki Mori, Kenji Yamauchi, Kazuya Kitamura, Tomoki Fujita, Katsuhiro Mabe, Tatsuya Mikami, Atsushi Goto, Makoto Akashi, Yoshihiko Hamamoto, Mitsuhiro Fujishiro, Isao Sakaida

Research output: Contribution to journalArticlepeer-review

Abstract

Characteristics of the chronotypes of patients with gastrointestinal disease are unknown. We evaluated chronotypes of patients with upper gastrointestinal diseases with the Munich ChronoType Questionnaire (MCTQ). A total of 2027 subjects from 29 institutions in Japan who had undergone esophagogastroduodenoscopy were asked to answer the MCTQ. The subjects’ chronotypes were divided into three groups (early, intermediate, and late chronotype) using the sleep-corrected mid-point of sleep on free days (MSFSC) values. According to their endoscopic diagnosis and abdominal symptoms, the subjects were divided into the reflux esophagitis (RE) group, gastroduodenal ulcer (GDU) group, upper gastrointestinal carcinoma (CA) group, functional dyspepsia (FD) group, non-FD group, and control group. In total, 1128 subjects were eligible for the analysis. The MSFSC (average ± standard deviation, clock hours, h) of each disease group was as follows: control group: 02.51 ± 1.22, non-FD group: 02.69 ± 1.14, FD group: 02.91 ± 1.19, RE group: 02.58 ± 1.05, GDU group: 02.47 ± 1.31, and CA group: 02.11 ± 1.08 h. Compared to the control group, the rate of late chronotype of the FD group significantly increased to 33.3%, whereas that of early chronotype of the CA group significantly increased to 38.3% (P = .0177 and 0.0036, respectively). In both the FD and CA groups, chronotype was the independent factor related to the diseases. The adjusted odds ratio of late chronotype to early chronotype was 3.01 [95% CI, 1.23–7.35] in the FD group and 0.44 [95% CI, 0.23–0.85] in the CA group. In conclusion, late chronotype was common in patients with FD, and early chronotype was common in patients with upper gastrointestinal carcinoma.

Original languageEnglish
JournalChronobiology International
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Chronotype
  • circadian rhythm
  • esophagoga- stroduodenoscopy
  • functional dyspepsia
  • munich chronotype questionnaire
  • upper gastrointestinal carcinoma

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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