Experimental transmission of Creutzfeldt-Jakob disease and related diseases to rodents

J. Tateishi, Tetsuyuki Kitamoto, M. Z. Hoque, H. Furukawa

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Sporadic Creutzfeldt-Jakob disease (CJD) with 129M/M, and iatrogenic and familial CJD with E200K and M232R, showed similar clinicopathologic features, a synaptic type deposition of PrP(CJD)), and high transmission frequencies to mice. Sporadic patients with 129M/V or 129V/V, and mutation cases with V180I, showed slightly different features and low or null transmission frequencies to mice. Hereditary cases with P102L, P105L, A117V, Y145stop, and insertions had different features but all demonstrated a long clinical duration and the presence of PrP plaques. The experimental transmission to mice of these mutant forms was difficult, except for one-third of the cases with P102L. CJD and related diseases, even those that are hereditary, may thus be divided into two different groups, those that are easily transmissible and those that are either difficult to transmit or nontransmissible.

Original languageEnglish
Pages (from-to)532-537
Number of pages6
JournalNeurology
Volume46
Issue number2
DOIs
Publication statusPublished - 1996 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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