Experimental tooth movement upregulates preproenkephalin mRNA in the rat trigeminal nucleus caudalis and oralis

Tarek A. Balam, Takashi Yamashiro, Li Zheng, Sakhr Murshid Ahmed, Yoshiaki Fujiyoshi, Teruko Takano-Yamamoto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Levels of preproenkephalin mRNA expression in trigeminal subnucleus complex by noxious tooth movement stimuli were examined using in situ hybridization. At 24 h, preproenkephalin mRNA expression was significantly upregulated in the ipsilateral trigeminal subnucleus caudalis (P < 0.05), and in the subnucleus oralis (P < 0.05). These findings suggested that enkephalinergic inhibitory systems could be activated during tooth movement, and that subnucleus oralis may be involved in modulation of the nociception, as well as the subnucleus caudalis.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalBrain research
Volume1036
Issue number1-2
DOIs
Publication statusPublished - 2005 Mar 2
Externally publishedYes

Keywords

  • Pain modulation
  • Preproenkephalin
  • Subnucleus caudalis
  • Subnucleus oralis
  • Tooth movement

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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