Experimental study to form microbubble aggregations for cell delivery using ultrasound

Fumi Demachi, Ren Koda, Jun Koido, Takashi Mochizuki, Kohji Masuda, Shin Enosawa, Toshio Chiba

Research output: Contribution to journalArticlepeer-review


Recently, though treatment to inject activated cells to a patient is popular, there’re some side effects and limitation of accumulation efficiency, because the cells spread in bloodstream. Therefore, we have previously reported our attempts for active control of microbubbles (MBs) by using Bjerknes force. In this study, we examined the method to form aggregations including cells (lymphocyte) derived from a rat. After the injection of the MBs and cells, we emitted ultrasound with frequency of 5 MHz and sound pressure of 300 kPa-pp. Figure shows the comparison of aggregations without cells. We estimate cells were included in aggregations, which can be predicted the controllability of cells.

Original languageEnglish
Pages (from-to)O-217-O-218
JournalTransactions of Japanese Society for Medical and Biological Engineering
Publication statusPublished - 2014 Aug 17


  • Aggregation
  • Cell delivery
  • Microbubble
  • Ultrasound

ASJC Scopus subject areas

  • Biomedical Engineering


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