Experimental study to form microbubble aggregations for cell delivery using ultrasound

Fumi Demachi; Ren Koda; Jun Koido; Takashi Mochizuki; Kohji Masuda; Shin Enosawa; Toshio Chiba

doi:10.11239/jsmbe.52.O-217

Experimental study to form microbubble aggregations for cell delivery using ultrasound

Fumi Demachi, Ren Koda, Jun Koido, Takashi Mochizuki, Kohji Masuda, Shin Enosawa, Toshio Chiba

ENG - Materials Processing

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, though treatment to inject activated cells to a patient is popular, there’re some side effects and limitation of accumulation efficiency, because the cells spread in bloodstream. Therefore, we have previously reported our attempts for active control of microbubbles (MBs) by using Bjerknes force. In this study, we examined the method to form aggregations including cells (lymphocyte) derived from a rat. After the injection of the MBs and cells, we emitted ultrasound with frequency of 5 MHz and sound pressure of 300 kPa-pp. Figure shows the comparison of aggregations without cells. We estimate cells were included in aggregations, which can be predicted the controllability of cells.

Original language	English
Pages (from-to)	O-217-O-218
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	52
DOIs	https://doi.org/10.11239/jsmbe.52.O-217
Publication status	Published - 2014 Aug 17

Keywords

Aggregation
Cell delivery
Microbubble
Ultrasound

ASJC Scopus subject areas

Biomedical Engineering

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10.11239/jsmbe.52.O-217

Cite this

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AU - Demachi, Fumi

AU - Koda, Ren

AU - Koido, Jun

AU - Mochizuki, Takashi

AU - Masuda, Kohji

AU - Enosawa, Shin

AU - Chiba, Toshio

PY - 2014/8/17

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N2 - Recently, though treatment to inject activated cells to a patient is popular, there’re some side effects and limitation of accumulation efficiency, because the cells spread in bloodstream. Therefore, we have previously reported our attempts for active control of microbubbles (MBs) by using Bjerknes force. In this study, we examined the method to form aggregations including cells (lymphocyte) derived from a rat. After the injection of the MBs and cells, we emitted ultrasound with frequency of 5 MHz and sound pressure of 300 kPa-pp. Figure shows the comparison of aggregations without cells. We estimate cells were included in aggregations, which can be predicted the controllability of cells.

AB - Recently, though treatment to inject activated cells to a patient is popular, there’re some side effects and limitation of accumulation efficiency, because the cells spread in bloodstream. Therefore, we have previously reported our attempts for active control of microbubbles (MBs) by using Bjerknes force. In this study, we examined the method to form aggregations including cells (lymphocyte) derived from a rat. After the injection of the MBs and cells, we emitted ultrasound with frequency of 5 MHz and sound pressure of 300 kPa-pp. Figure shows the comparison of aggregations without cells. We estimate cells were included in aggregations, which can be predicted the controllability of cells.

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Experimental study to form microbubble aggregations for cell delivery using ultrasound

Abstract

Keywords

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