Abstract
Background: Perfluoro-octyl bromide (PFOB), one of the perfluorochemical oxygen transporters, improved postischemic cardiac dysfunctions. Also norepinephrine (NE) is one of the important inducible factors on reperfusion arrhythmias (ventricular fibrillation [VF]). We used these methods to evaluate the relationship between PFOB emulsion and NE release on reperfusion arrhythmias. Materials and Methods: The perfusion of isolated guinea pig hearts was employed: each of four groups of 6-7 hearts were used with Krebs-Henseleit solution (KHS) as control, and KHS with 5%, 15%, or 30% PFOB emulsion. The hearts were perfused in a constant pressure Langendorff model, stabilized for 30 min, followed by 30 min preischemia, then 30 min ischemia and 45 min reperfusion at normothermia. Results: PFOB emulsion dose-dependently limited VF and inhibited NE release in reperfusion. Only 30% PFOB emulsion showed the significant improvement of VF (p = 0.05). In hemodynamic parameters, only 5% PFOB emulsion showed a significant decrease in reperfusion, but there was no difference in coronary flow rate (CFR). No differences among the four groups were demonstrated in cardiac oxygen metabolic parameters. Conclusions: It was most likely that a high concentration of PFOB emulsion attenuated reperfusion arrhythmia by decreasing NE release. (Ann Thorac Cardiovasc Surg 2008; 14: 363-368)
Original language | English |
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Pages (from-to) | 363-368 |
Number of pages | 6 |
Journal | Annals of Thoracic and Cardiovascular Surgery |
Volume | 14 |
Issue number | 6 |
Publication status | Published - 2008 Dec |
Keywords
- Norepinephrine
- Perfluoro-octyl bromide
- Reperfusion arrhythmia
- Ventricular fibrillation
ASJC Scopus subject areas
- Surgery
- Pulmonary and Respiratory Medicine
- Cardiology and Cardiovascular Medicine
- Gastroenterology