Experimental study of active control of microbubbles in blood flow by forming their aggregations

Kohji Masuda, Ren Koda, Nobuyuki Watarai, Nobuhiko Shigehara, Takumi Ito, Takashi Kakimoto, Yoshitaka Miyamoto, Shin Enosawa, Toshio Chiba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

16 Citations (Scopus)


We have experimented a method to control behavior of microbubbles in flow using an artificial blood vessel with multiple transducers to emit ultrasonic plane wave. Microbubbules are propelled in flow owing to a primary Bjerknes force, which is a physical phenomenon where an acoustic wave pushes an obstacle along its direction of propagation. Also they form aggregation when they are put into an ultrasound field because of secondary Bjerknes force, which acts as attractive or repulsive factor among neighboring microbubbles. Thus we consider that forming bubble aggregations is effective to be propelled before entering into an ultrasound field to receive greater primary Bjerknes force. We have investigated the phenomenon of bubble aggregations and observed behavior of aggregations with and without red blood cells in artificial blood vessels under various conditions of ultrasound exposure. As the results, when microbubble aggregations were formed, the efficiency was improved more than the condition without forming aggregation. The existence of red blood cells near microbubbles contributed to the increase in the size of aggregations propelled against the vessel wall.

Original languageEnglish
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Number of pages4
Publication statusPublished - 2011 Dec 1
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: 2011 Oct 182011 Oct 21

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Other2011 IEEE International Ultrasonics Symposium, IUS 2011
Country/TerritoryUnited States
CityOrlando, FL


  • Active path selection
  • Bjerknes force
  • Microbubble aggregation
  • Red blood cell

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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