In order to treat the patients with lung cancer who have impaired cardiopulmonary f a new method is designed, which includes following steps. 1. Pneumonectomy. 2. Resection of tumor-bearing lobe. 3. 60Co irradiation to the remaining lobe. 4. Orthotopic reimplantation of the irradiated lung. The purpose of present study is to clarify the feasibility to use this method clinically. Using adult mongrel dogs, left lung was excised, irradiated and reimplanted. Radiation was carried out from 2,000 rad to 4,000 rad. Viability and function of reimplanted lungs were evaluated by their survival time, serial chest X-ray films, (99m)Tc-MAA perfusion scannings, unilateral pulmonary artery occlusion test and histologic examinations. Of 17 animals, 12 survived postoperative period and following results were obtained. 1. No dogs developed pulmonary edema. 2. Only one dog was considered to die from acute radiation pneumonitis. 3. Serial perfusion scannings showed a gradual decrease in flow distribution to the transplanted lung. 4. The right pulmonary occlusion test done in the dog irradiated with 2,000 rad revealed well reserved pulmonary function 2 months after the operation. 5. Histologically, most irradiated lungs revealed so-called 'late reaction' or lung fibrosis, but there was the case with nearly normal findings after 6 months from the operation. Although many reports concerning the radiation pneumonitis are published, there have not been any such reports as the present study. From authors' experiment, it may be indicated that there is a feasibility to use this new method clinically.
|Number of pages||7|
|Journal||Journal of the Japanese Association for Thoracic Surgery|
|Publication status||Published - 1978 Dec 1|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine