Experimental Helicobacter pylori infection in association with other bacteria

Hiroshi Isogai, Emiko Isogai, Shunji Hayashi, Koichi Kimura, Toru Kubota, Nobuhiro Fujii, Keiji Oguma

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


We performed surgical treatment on normal ddY mice before Helicobacter pylori inoculation. The treatment was expected to obstruct bacterial flow out of the stomach and increase the chance of bacterial attachment to the gastric epithelium in mice. The bacterial challenge induced inflammation in the stomach. H. pylori was recovered from the stomach throughout the observation period. Lactobacilli and streptococci tended to relate to the increase in number of H. pylori recovered. Pretreatment with atropine was considered to confuse the gastric flora and affect the number of H. pylori recovered. These results suggested that a certain amount of time is necessary for H. pylori to contact with the gastric epithelium and that the composition of flora is important for the establishment of H. pylori infection.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
Issue number4
Publication statusPublished - 1997


  • Atropine
  • Gastritis
  • Helicobacter pylori
  • Lactobacilli
  • Mouse model
  • Streptococci

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology


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